cornea interface tear film

Ocular Science · Pharma & Cosmetics · In Vitro + In Silico

De-risk your ocular
formulations — before
they reach the market

Eyveris provides the first integrated in vitro and in silico tear film and cornea testing platform — enabling mechanistic, animal-free assessment of ocular irritation, compatibility, and formulation performance — for pharmaceutical and cosmetic products alike.

Request a Feasibility Study Explore the Platform
10+
Years of Underlying Research
2
Integrated Model Platforms
100%
Animal-Free Methodologies
4
Co-founders, all PhD Scientists
Collaboration areas
Ophthalmic Pharma Cosmetic & Periocular OTC Lubricants Biocompatible Implants Contact Lens Systems Drug Nanocarriers
lipid aqueous Tear Film glycocalix Corneal Surface lipid adsorption implant surface Implantable Material lipid layer In Silico Modeling

About Eyveris

Tear film & cornea–driven
formulation testing — for pharma and cosmetics

Eyveris is a research-driven startup built on over 10 years of basic research in tear film biophysics, corneal surface science, and interfacial phenomena. We translate that science into decision-enabling tools for pharmaceutical and cosmetics companies.

Our platform serves both pharmaceutical developers navigating regulatory requirements and cosmetics formulators seeking independent, science-backed evidence of ocular compatibility — delivering the same mechanistic rigour to both.

We operate at the intersection of academic rigor and industrial relevance — delivering reproducible, interpretable results that hold up in both publication and regulatory settings.

Animal-Free Peer-Reviewed Methods Regulatory-Compatible EU Cosmetics Regulation–Aware Prague, CZ

Services

What we offer

Integrated testing and R&D support built on our proprietary tear film and cornea models, tailored to your compound type, development stage, and regulatory context.

Ocular Safety & Irritation

Mechanistic, quantitative assessment of tear film destabilization and breakup. Fully animal-free, fully reproducible.

"Know if your formula will irritate patients — before Phase I begins."

Formulation Development

Mechanistic insight into how your excipients, preservatives, and polymers interact with the tear film and corneal surface.

"Make smarter formulation choices with data, not intuition."

Biocompatibility Testing

Assess polymeric implants, contact lens materials, cosmetic ingredients, and microplastic by-products against the ocular lipid environment.

"Independent verification your materials won't compromise eye health."

Technology Platform

Our integrated
in vitro + in silico models

In Vitro

Tear Film Platform

A proprietary acellular tear film interface combining an aqueous phase with a lipidomics-guided complex lipid multilayer — enabling direct assessment of how formulations interact with and disrupt the tear layers.

  • Real-time tear film destabilization and breakup analysis
  • Structural changes at the ocular interface
  • Simulated blinking cycles
  • Drug partitioning at tear lipid and aqueous layers
In Vitro

Corneal Interface Platform

A glycocalyx-relevant, acellular corneal-interface mimic built to reflect the key interfacial features that govern irritation-relevant interactions at the ocular surface.

  • Corneal surface compatibility assessment
  • Polymer–cornea interactions
  • Preservative mechanism profiling
  • Biocompatibility screening
In Silico

Molecular Dynamics Simulations

Coarse-grained and atomistic MD simulations that resolve drug–lipid, excipient–membrane, and nanocarrier dynamics at molecular resolution — delivering mechanistic insight unavailable from experiment alone.

  • Drug–lipid and excipient–tear lipid interactions
  • Nanocarrier passage and decomposition
  • Molecular-resolution mechanism elucidation
  • Rational formulation troubleshooting
Data & Software

Proprietary Analysis Pipelines

Beyond models, we develop specialized data analysis methodologies, proprietary software tools, and standardized workflows that ensure results are reproducible, interpretable, and defensible.

  • Automated destabilization quantification
  • Standardized reporting workflows
  • Custom software for ocular data
  • Regulatory-ready documentation
◆

The first integrated in vitro + in silico platform dedicated exclusively to ocular formulation testing — combining advanced tear film and cornea models with specialized data analysis and standardized workflows.

Our Team

Scientists who understand
both worlds

Prof. Lukasz Cwiklik
Prof. Lukasz Cwiklik
CEO

Expert in tear film biophysics and molecular simulations. Professor with 15+ years of fundamental and applied ocular surface research.

Dr. Katarina Vazdar
Dr. Katarina Vazdar
CSO

Surface and interface chemistry specialist with deep expertise in lipid membrane systems and formulation science.

Dr. Wojciech Pajerski
Dr. Wojciech Pajerski
CTO

Leads platform development and proprietary software tools. Expert in experimental methodology, data pipelines, and reproducibility.

Dr. Martin Kubeš
Dr. Martin Kubeš
CBO

Bridges science and business. Leads partnerships and commercial strategy with deep experience in pharma and biotech collaboration.

Applications

Where we can help

Pharmaceutical

Ophthalmology

  • Artificial tears and OTC lubricants
  • Prescription eye drops — glaucoma, dry eye disease
  • Nanocarrier formulations for ocular drug delivery
  • Preservative selection and strategy
  • Excipient screening and mechanistic profiling
Cosmetics & Consumer

Periocular Products

  • Cosmetics with ocular or periocular exposure
  • Artificial eyelashes, glues, and removers
  • Independent verification of low-irritation claims
  • Benchmarking against competitor formulations
  • Microplastic impact on ocular surface

Reference Work

Built on peer-reviewed science

Drug Delivery Systems

Latanoprost Formulations

Comparative analysis of delivery systems and their impact on tear film lipid layer stability, directly linking formulation design choices to ocular surface behavior and tolerability.

Preservative Safety

BAK Mechanism of Action

Mechanistic evaluation of benzalkonium chloride effects on tear film lipid layer structure and function, providing molecular-level evidence to inform safer preservative strategies.

Molecular Interactions

Drug–Lipid Incorporation

Combined in vitro and in silico studies on drug integration into tear film lipids, revealing molecular-level interactions directly relevant to tolerability and bioavailability.

Biocompatibility

Polymer–Lipid Interactions

Biocompatibility assessment of polymers used in ophthalmic implants and devices, with focus on lipid layer interaction as a key indicator of ocular surface compatibility.

Contact

Let's talk about
your formulation challenge

Whether you're early-stage screening or need mechanistic root-cause analysis, we'll scope a study to fit your needs.

Location
Prague, Czech Republic
Address
Dolejškova 2155/3
Email
contact@eyveris.com
Registration
Eyveris s.r.o. · IČO 24490580